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The effects of date rape drugs vary from person to person. They depend on the victims' physical condition, health, dosage, and how much food is in the stomach. Date rape drugs can be life-threatening if ingested in combination with alcohol or other drugs.

Most often, victims experience nausea or vertigo immediately after ingesting the drugs – it feels somewhat similar to having drunk too much. Only later do they loseconsciousness. Their movements and conversation are relatively normal until then, yet they are easily manipulated and become passive.

After waking up the victim is only able to vaguely remember what happened while s/he was unconscious, as well as the events immediately preceding that, or may not have any recollection at all.

An overdose of date rape drugs can be dangerous: they can lead to heart failure,respiratory failure, coma or death if combined with alcohol, medication or other party drugs.

You'll find detailed information about the effect of date rape drugs here
What are date rape drugs? > effects