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Date rape drugs / K.O. drops are substances that cause the victim to lose
consciousness and become helpless or incapacitated. The terms may refer to a
number of active agents that are used as anaesthetics or sedatives in medicine. Some of these drugs are liquid, but they can also come as powders or pills. Criminals use these drugs to incapacitate their victims during sexual assault or robbery.

Substances used as date rape drugs include:

GHB and GBL

Gamma-hydroxybutyrate (GHB) or gamma-butyrolactone (GBL, precursor of GHB) – known as "liquid ecstasy," "liquid E" or "liquid X" in the party scene. GHB was developed as an anaesthetic, but is now seldom used in medicine. Chemically it isn't related to amphetamines or ecstasy (MDMA) and doesn't have the same effects. GBL is a predecessor to GHB that is converted to GHB in the body.

Ketamin

Ketamine is used as an anaesthetic in veterinary medicine and as a painkiller in
human emergency medicine.

Benzos, flunis, roofies

These names designate prescription sedatives and psychotropic drugs stemming from the benzodiazepines group such as flunitrazepam (trade name Rohypnol), Alprazolam (trade name Xanax), diazepam (trade name Valium).

There are slight differences regarding when the substances act and for how long.
What all substances have in common, however, is that they restrict movement and
action and can lead to deep, coma-like sleep and unconsciousness.